"The weekly injection continues each early Friday evening, though I am now beginning to wean off the medication. The plan is to extend intervals gradually: every other week, then every three weeks, then monthly, then complete cessation. The changes appear permanent."
As a post-menopausal woman who has lost my desire to consume simple carbs and alcohol AND 30 post-pandemic pounds since taking ZepBound, I also ask whether these desires and weight will return without the med. I know one person who intends to take it her entire life because her body doesn’t produce the satiety hormone (she was medically obese most of her life). As someone who was thin most of her life, I am using the med therapeutically to return to my old set point and a healthier lifestyle, and to retrain my dopamine receptors. CBT therapy would be beneficial to achieve long-term results with this approach. But if I had to be on any medication for the rest of my life (as some do), I would prefer this class of drugs over insulin, statins, high-blood pressure meds, cancer inhibitors, arthritis meds, anti-inflammatories, antidepressants, HRT etc. The effect on the body and mind has been life-changing.
Well done Brian. GLP-1 agonists and their second and third generation peptides are an exceptional breakthroughs for our health. It’s worth it for our families to let go of old attitudes on health & suffering. Lisa and your girls deserve a long and healthy lifetime with you.
Thank you for such a kind compliment. I’ve been enjoying your posts here quite a bit so I’m glad to have helped nudge you in the direction of posting more of your writing.
This is fantastic, Brian. Thank you for your leadership on this—and on a personal note, I’m so happy for you.
As a gynecologist specializing in midlife and menopause, I can’t help but see strong parallels with hormone therapy for women. In both cases, we have highly effective, evidence-based treatments that are held back by public misunderstanding, fear of side effects, and limited access—often due to hesitant or misinformed healthcare providers and restrictive insurance policies. These are powerful tools that can profoundly improve health and quality of life. We need more articles like this to educate, empower, and get people TALKING!
Can you share more about micro dosing ozempic? Did your doctor prescribe you a standard dose and then you are titrating off that dosage over time on your own schedule? How long were you on the full program before you starting weaning yourself off?
It IS a medical breakthrough. But as you hinted, not without its consequences to the market. Today’s food, entertainment, advertising and agricultural industries are rooted in the public’s overconsumption of simple carbohydrates (including alcohol, sugars, junk food) in addition to big pharma’s profits in treating the secondary diseases resulting therefrom. Cultural and medical acceptance of this life changing class of drugs and the health and wellness industries are competing against larger and firmly entrenched interests. Thank you for doing your part to spread the word!
Thanks for sharing and not gatekeeping! Love this topic. Tim Ferris noted in his book "Tools of Titans" that a lot of high profile individuals were taking metformin for longevity purposes. Ferris has been taking it himself for a long time apparently and it really got me thinking.... I've always known blood sugar balance to be the foundation of all health but its just becoming clearer and clearer. It's been a biohacking tool for years but now is it time to actually consider it for widespread public health use? I'm worried about side effects but i think the pros outweigh the cons...
Great post - does this mean that you now have to be on GLP1 your entire life to sustain the gain? what happen when someone stop the medication?
"The weekly injection continues each early Friday evening, though I am now beginning to wean off the medication. The plan is to extend intervals gradually: every other week, then every three weeks, then monthly, then complete cessation. The changes appear permanent."
As a post-menopausal woman who has lost my desire to consume simple carbs and alcohol AND 30 post-pandemic pounds since taking ZepBound, I also ask whether these desires and weight will return without the med. I know one person who intends to take it her entire life because her body doesn’t produce the satiety hormone (she was medically obese most of her life). As someone who was thin most of her life, I am using the med therapeutically to return to my old set point and a healthier lifestyle, and to retrain my dopamine receptors. CBT therapy would be beneficial to achieve long-term results with this approach. But if I had to be on any medication for the rest of my life (as some do), I would prefer this class of drugs over insulin, statins, high-blood pressure meds, cancer inhibitors, arthritis meds, anti-inflammatories, antidepressants, HRT etc. The effect on the body and mind has been life-changing.
Well done Brian. GLP-1 agonists and their second and third generation peptides are an exceptional breakthroughs for our health. It’s worth it for our families to let go of old attitudes on health & suffering. Lisa and your girls deserve a long and healthy lifetime with you.
Thanks, Julie! Been fun to catch up. Your daily writings have been a big inspiration for me to start writing.
Thank you for such a kind compliment. I’ve been enjoying your posts here quite a bit so I’m glad to have helped nudge you in the direction of posting more of your writing.
This is fantastic, Brian. Thank you for your leadership on this—and on a personal note, I’m so happy for you.
As a gynecologist specializing in midlife and menopause, I can’t help but see strong parallels with hormone therapy for women. In both cases, we have highly effective, evidence-based treatments that are held back by public misunderstanding, fear of side effects, and limited access—often due to hesitant or misinformed healthcare providers and restrictive insurance policies. These are powerful tools that can profoundly improve health and quality of life. We need more articles like this to educate, empower, and get people TALKING!
Can you share more about micro dosing ozempic? Did your doctor prescribe you a standard dose and then you are titrating off that dosage over time on your own schedule? How long were you on the full program before you starting weaning yourself off?
GLP-1 drugs are in the Longevity category. Micro-dosing it is ⭐️ Anyone who says “cheating” has issues.
Getting to a healthy weight should be everyone’s goal.
Love the before and after. Shame you lost two daughters on the way. Lol.
Looking great, Brian! 🙌
It IS a medical breakthrough. But as you hinted, not without its consequences to the market. Today’s food, entertainment, advertising and agricultural industries are rooted in the public’s overconsumption of simple carbohydrates (including alcohol, sugars, junk food) in addition to big pharma’s profits in treating the secondary diseases resulting therefrom. Cultural and medical acceptance of this life changing class of drugs and the health and wellness industries are competing against larger and firmly entrenched interests. Thank you for doing your part to spread the word!
So incredibly well said. You nailed the judgement piece better than I’ve been able to articulate. Perfect. Thank you.
Thanks for sharing and not gatekeeping! Love this topic. Tim Ferris noted in his book "Tools of Titans" that a lot of high profile individuals were taking metformin for longevity purposes. Ferris has been taking it himself for a long time apparently and it really got me thinking.... I've always known blood sugar balance to be the foundation of all health but its just becoming clearer and clearer. It's been a biohacking tool for years but now is it time to actually consider it for widespread public health use? I'm worried about side effects but i think the pros outweigh the cons...
Also - you definitely look like your biologically 32! Proof is in the pudding.